Prion Protein, aa79-97, NT (PrP, CD230) (Not for Export EU)

Size

£767.00

SKU:: P8950-20
Purity:: Serum.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Goat
Immunogen:: Synthetic peptide corresponding to aa79-97 of the N-terminus of the human PrP.
Format:: Supplied as a liquid, 0.01% thimerosal.
Extra Details:: The prion protein is a large membrane protein that occurs normally in neurons of the human brain. It is thought to be involved in synaptic transmission. In prion diseases (such as CJD, Gerstmann-Straussler-Scheinker syndrome (GSS), Fatal Familial Insomnia (FFI), Alpers Syndrome and Kuru) the normal cellular form of this protein (PrPc) is transformed into an altered protein when it comes into contact with an infectious prion protein (PrPsc) from another host. This altered PrPsc accumulates in cytoplasmic vesicles of diseased individuals forming lesions, vacuoles and amyloid deposits. Applications: Suitable for use in Immunohistochemistry, Western Blot and ELISA. Other application not tested. Recommended Dilutions: Immunohistochemistry: >1:200 on paraffin embedded, formalin fixed human brain. Western Blot: >1:2000 ELISA: >1:35,000 Optimal dilutions to be determined by researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.