Presenilin 1

Size

£754.00

SKU:: P6300-36B
Purity:: Purified by immunoaffinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide corresponding to 15aa near the C terrminal, cytoplasmic domain of human/mouse Presenilin-1. Species Sequence Homology: monkey, Xenopus, mouse and rat; 100%, bovine; 85%.
Format:: Supplied as a liquid in PBS, 0.1% BSA.
Extra Details:: Alzheimer's Disease (AD) is a neurodegenerative disorder characterized by progressive loss of memory and cognition in the elderly. A number of genes have been linked in the initiation and development of AD. One of the most important and initial step involves proteolytic cleavage of amyloid precursor protein (APP, chromosome 21) releasing short 40, 42 & 43aa peptides (b amyloid 1-40, 1-42, and 1-43). Polymerization of b-amyloid (Ab) and subsequent neuronal deposit (amyloid) leads to the degeneration of neurons involved in memory and cognition. Mutations in the APP gene cause some forms of familial AD (FAD) by releasing an increased amounts of b-amyloid. The AD Ab deposits also contain anti-chymotrypsin (ACT), and Apolipoprotein (Apo-E) that may promote Ab polymerization. Applications: Suitable for use in ELISA. Western Blot, though not tested, may potentially be used as an application. Other applications not tested. Recommended Dilutions: ELISA: 1:10,000-1:100,000 using 50-100ng of control peptide/well Western Blot: 1-10ug/ml using ECL. Optimal dilutions to be determined by the researcher. Control Peptide: P6300-36A: Presenilin 1, Human, Control Peptide Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice