P4445
Polyglutamine (Polyglutamine Expansion Disease Marker)
Size
£891.00
- SKU:
- P4445
- Purity:
- Ascites
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- N-terminal part of the human TATA Box Binding Protein (TBP).
- Clone:
- 2Q131
- Format:
- Supplied as a liquid. No preservatives added.
- Extra Details:
- Polyglutamine-containing proteins are recognized, notably those involved in several human neurodegenerative diseases caused by a CAG repeat expansion, like Huntington’s disease and spinocerebellar ataxia type 2, 3 and 7. This antibody has been used to identify new neurodegenerative diseases caused by polyglutamine expansion and to help for cloning of the corresponding affected genes. This monoclonal antibody is also able to detect intracellular inclusions, which is a hallmark of such diseases. Shows greater detection of the pathological proteins that contain a polyglutamine expansion (37 glns) than the wild type proteins. Applications: Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry and Immunoprecipitation. Other applications have not been tested. Recommended Dilutions: ELISA: 1:1000-1:20,000 Western Blot: 1:1000-1:20,000 Immunohistochemistry (Frozen & paraffin): 1:1000-1:20,000 Immunocytochemistry: 1:1000-1:20,000 (transfected cells) Immunoprecipitation: 1:1000-1:20,000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice