P4256-29X

Plasminogen Activator Inhibitor Type 1, Wild Type Latent, Rat (HEPES Buffer) (PAI-1)

Size

£1,610.00

SKU:: P4256-29X
Molecular Weight:: 43
Purity:: ≥95% (SDS-PAGE)
Storage Conditions:: -70°C
Supplier:: United States Biological
Format:: Supplied as a liquid in 0.1M HEPES, pH 7.4, 0.1M sodium chloride.
Extra Details:: Plasminogen Activator Inhibitor 1 (PAI-1) is a glycoprotein found in plasma that is implicated in the processes of angiogenesis, hemostasis, tumor metastasis, fibrionlysis, ovulation, embryonic development and inflammation. The elevation of PAI-1 has shown to correlate with the prognosis of many cancers including breast cancer. PAI-1 is activated by the glycoprotein vitronectin. Vitronectin binds to PAI-1 and modulates fibrinolysis and cell migration. This binding has proven to be an important inhibitor of the activated form of protein C (APC). Concentration of Active PAI-1: Not detectable by SDS-PAGE Solubility: >2mg/ml and <5mg/ml Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for 6 months after receipt.