Plasminogen Activator Inhibitor Type 1, latent wild type, Human (PAI-1)

Size

£1,501.00

SKU:: P4256-29L
Molecular Weight:: 43
Purity:: ≥98% pure by SDS PAGE
Storage Conditions:: -70°C
Supplier:: United States Biological
Format:: Supplied as a liquid in 0.05M sodium phosphate, 0.1M sodium chloride, pH 6.6, 1mM EDTA.
Extra Details:: Plasminogen Activator Inhibitor 1 (PAI-1) is a glycoprotein found in plasma that is implicated in the processes of angiogenesis, hemostasis, tumor metastasis, fibrinolysis, ovulation, embryonic development and inflammation (1). The elevation of PAI-1 has shown to correlate with the prognosis of many cancers including breast cancer (2,3,4). PAI-1 is activated by the glycoprotein vitronectin. Vitronectin binds to PAI-1 and modulates fibrinolysis and cell migration (5). This binding has proven to be an important inhibitor of the activated form of protein C (APC) (6). Activity: <0.4% active Applications: Suitable for use as control for experiments when used in conjunction with the active form of PAI-1 Storage and Stability: For long-term storage, aliquot to avoid repeated freezing and thawing and freeze at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for 6 months after receipt.