P4256-29B

Plasminogen Activator Inhibitor Type 1, active wild type, Human Recombinant (PAI-1)

Size

£541.00

SKU:: P4256-29B
Molecular Weight:: 43
Purity:: ≥ 98% pure by SDS PAGE.
Storage Conditions:: -70°C
Supplier:: United States Biological
Format:: Supplied as a liquid in PBS, 1mM EDTA, pH 6.6.
Extra Details:: Plasminogen Activator Inhibitor 1 (PAI-1) is a glycoprotein found in plasma that is implicated in the processes of angiogenesis, hemostasis, tumor metastasis, fibrionlysis, ovulation, embryonic development and inflammation (1). The elevation of PAI-1 has shown to correlate with the prognosis of many cancers including breast cancer (2,3,4). PAI-1 is activated by the glycoprotein vitronectin. Vitronectin binds to PAI-1 and modulates fibrinolysis and cell migration (5). This binding has proven to be an important inhibitor of the activated form of protein C (APC) (6). Appearance: Colorless frozen solution Solubility: > 2mg/ml and < 5mg/ml Storage and Stability: For long-term storage, aliquot and store at -70°C. Aliquots are stable for 6 months after receipt at -70°C. Further dilutions can be made in assay buffer.