P4210-63

PKC412 (4'-N-Benzoyl Staurosporine, CGP 41251, Midostaurin)

Size

£244.00

SKU:: P4210-63
Molecular Weight:: 570.64
Purity:: ≥99%
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 120685-11-2
Format:: Supplied as off-white to beige, tan or yellow solid.
Extra Details:: The staurosporine analog, PKC412, inhibits a variety of serine/threonine and tyrosine kinases including PKC (IC50=50nM), cyclic AMP-dependent protein kinase (IC50=2.4uM), S6 kinase (IC50=5.0uM), and EGFR (epidermal growth factor receptor) tyrosine-kinase activity (IC50=3.0uM). CAS Number: 120685-11-2 Molecular Formula: C35H30N4O4 Molecular Weight: 570.64 Appearance: Supplied as off-white to beige, tan or yellow solid.. Purity: ≥99% Solubility: Soluble in DMSO at 100mg/ml and in ethanol at 5mg/ml with warming. Very poorly soluble in water; maximum solubility in water is ~10-20uM; buffers, serum or other additives may increase or decrease aqueous solubility. Storage and Stability: Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.