P3970

Phomopsin A

Size

£526.00

SKU:: P3970
Molecular Weight:: 789.2
Purity:: ≥98% (HPLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 64925-80-0
Format:: Supplied as a white solid.
Extra Details:: Phomopsin A is an acidic 13-membered cyclic hexapeptide-like metabolite with three unusual amino acids linked in an "ansa" macrocycle with a three amino acid "tail", terminating in a dicarboxylic acid. Phomopsin A is a potent mycotoxin produced by the fungus Phomopsis leptostromiformis and is the causative agent of lupinosis in livestock fed infected lupins. Phomopsin A is an important bioprobe for understanding cellular structural proteins. It acts by selectively binding to dimeric tubulin, inhibiting the formation of the microtubule spindle to block cell division. Phomopsin A binds to tubulin at a site overlapping that of vinblastine and maytansine. Uniquely, phomopsin A protects tubulin from decay. Source: Phomposis leptostromiformis MST-FP2068 Solubility: Soluble in ethanol, methanol, DMF or DMSO. Slightly soluble in water. Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20°C. Stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.