P3272-04A

Pepsinogen I

Size

£1,055.00

SKU:: P3272-04A
Purity:: Ascites
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Pepsinogen I purified from human tissue
Clone:: 4C6.1
Format:: Supplied as a liquid in PBS, 1% BSA, 0.09% sodium azide.
Extra Details:: Pepsinogen I is a group of precursor molecules for pepsin. These proteins are solely synthetized and secreted into gastric lumen by chief (pepsin) cells and mucous neck cells in the gastric corpus (oxyntic mucosa). In atrophic corpus gastritis these cells disappear resulting in a decrease of the serum level of pepsinogen I and in a reduction of the number of pepsinogen I positive cells in gastric biopsies. The presence of positive immunostaining for pepsinogen I is a highly reliable sign for the acid-secreting oxyntic glands. In gastric heterotopia of the duodenal bulb, but not in gastric metaplasia, the oxyntic-type glands give a positive immunohistochemical reaction for pepsinogen I. Applications: Suitable for use in Immunohistochemistry, Western Blot and ELISA. Other applications not tested. Recommended Dilution: Immunohistochemistry: Paraffin Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after reciept.. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.