P1792-90
PACS1 (Phosphofurin Acidic Cluster Sorting Protein 1, PACS-1, KIAA1175)
Size
£537.00
- SKU:
- P1792-90
- Application:
- WB
- Purity:
- Purified by immunoaffinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide corresponding to aa300-350 of human PACS-1.
- Format:
- Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
- Extra Details:
- PACS-1 (CRA_a) is a 963aa rich regulatory protein involved in protein trafficking and belongs to the PACS family. A coat protein involved in controlling the correct subcellular localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs, PACS-1 is also known to be involved in HIV-1 Nef-mediated removal of MHC-I from the cell surface to the TGN, thus enabling HIV-1 to escape immune surveillance. PACS-1 also controls the endosome to Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin coated membrane pits. Usually seen in golgi apparatus, trans-Golgi network and localized in the paranuclear region, it is ubiquitously expressed in most of the tissues. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.05-0.1ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human uterus lysate Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice