O7700-01
ORAI2 (CAP-Binding Protein Complex-Interacting Protein 2)
Size
£655.00
- SKU:
- O7700-01
- Application:
- WB
- Purity:
- Purified by immunoaffinity chromatography.
- Storage Conditions:
- 4°C (-20°C Glycerol)
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- 15 amino acid peptide from near the carboxy terminus of human ORAI2 (UniProt # Q96SN7).
- Format:
- Supplied as a liquid in PBS, 0.02% sodium azide.
- Extra Details:
- Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels (1 for review). ORAI2 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC (2). Like ORAI1, ORAI2 has been shown to function as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor (3,4), although at a lesser efficacy than ORAI1 (4,5). This antibody is predicted to have no cross-reactivity to ORAI1 or ORAI3. Applications: Suitable for use in Western Blot and Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1-2 ug/ml. Immunocytochemistry: 5ug/ml. Optimal dilutions to be determined by the researcher. Positive Control: Jurkat cell lysate Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Shipping Conditions:
- Blue Ice