O7503

Orexin 1 Receptor (Hypocretin 1 Receptor) (Neat Serum) (Not for Export EU)

Size

£704.00

SKU:: O7503
Purity:: Neat serum
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptides, 16 aa, near the N-terminus of rat Orexin 1 Receptor (Hypocretin 1 Receptor) and a 16 aa peptide near the C-terminus of human.
Format:: Supplied as neat serum with preservative.
Extra Details:: Several peptides associated with feeding behavior have been reported recently. Orexins (Orexin A and Orexin B) are a family of hypothalamic neuropeptides selectively expressed in the hypothalamus and are derived from the same precursor (Prepro-orexin) by proteolytic cleavage. Prepro-orexin is 130 amino acid long peptide with a putative 33 AA secretory sequence, a hydrophobic core followed by residues with small polar side chains. The expression was detected in brain and to a small extent in testis. These neuropeptides bind and activate two closely related Orexin receptors—G-protein coupled receptors (GPCRs). Rat and human Orexin 1Receptor (Hypocretin 1 Receptor) are 416 aa, and 425aa, respectively. Applications: Suitable for use in ELISA, Western Blotting. Recommended Dilution: ELISA: 1:10,000-1:1000 (Use control peptides to confirm antibody specificity) Western Blotting: 1:1000-1:100,0 (use 50–100ng of control peptide/well; control peptides, because of their low MW (< 3kD), are not suitable for Western blot.