O7500-03B
Orexin A, aa1-33, Cyclized
Size
£544.00
- SKU:
- O7500-03B
- Purity:
- Purified by HPLC
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Format:
- Supplied as a lyophilized powder with no additives. Reconstitute with 1ml ddH2O and mix for 15 minutes at RT.
- Extra Details:
- Several peptides associated with feeding behavior have been reported recently. Orexins (Orexin-A and Orexin-B) are a family of hypothalamic neuropeptides selectively expressed in the hypothalamus. Orexin-A and Orexin-B are derived from the same precursor (Prepro-orexin) by proteolytic cleavage. Prepro-orexin is a 130aa long peptide with a putative 33aa secretory sequence, a hydrophobic core followed by residues with small polar side chains. The expression was detected in brain and to a small extent in testis. These neuropeptides bind and activate two closely related Orexin receptors- -G-protein coupled receptors (GPCRs) OX1R and OX2R. Source: Mouse/rat/human Orexin-A is a 33aa peptide. Full length Orexin-A peptide corresponding to aa1-33 (<EPL PDC CRQ KTC SCR LYE LLH GAG NHA AGI LTL-amide; <E is Pyroglutamic; 2 disulfides at Cys6-Cys12 & Cys7-Cys; mw: 3567.00) of the mouse (same in rat and human) Orexin A was synthesized. Activity: Full length Orexin-A has been shown to be biologically active. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Shipping Conditions:
- Blue Ice