NMDA 2a Receptor (NMDA R2a, N-methyl-D-aspartate) (Not for Export EU)

Size

£825.00

SKU:: N2905-10
Purity:: Serum
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: C-Terminal Fusion Protein of rat NMDAR2A (30kD), aa1253-1391.
Format:: Supplied as a liquid. No preservative added.
Extra Details:: The ion channels activated by glutamate are divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by kainate and a-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as kainate/AMPA receptors (K/AMPAR). NMDA receptors are among the most studied receptors in neuroscience because they are involved in neuronal cell development and plasticity, a cellular correlate for learning. NMDA receptors are also implicated in several disorders of the central nervous system including epilepsy and ischemic neuronal cell death. NMDA receptors also appear to be a target for ethanol at physiological concentrations and therefore may play a significant role in alcoholism. Applications: Suitable for use in Western Blot, Immunoprecipitation. Not recommended for use in Immunohistochemistry. Other applications not tested. Recommended Dilutions: Western Blot: 1:200 for labeled protein A, 1:1000-1:5000 for ECL (NMDAR2A is present in high concentrations in the hippocampus), Immunoprecipitation: Using solubilized hippocampal slices. 3ul will (under appropriate conditions) quantitatively immunoprecipitate all NMDAR2A in 200ug rat brain. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice