Nilotinib, Free Base (AMN107)

Size

£190.00

SKU:: N2567-18
Molecular Weight:: 529.52
Purity:: ~99% (by HPLC and TLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 641571-10-0
Format:: Supplied as an off-white powder
Extra Details:: Nilotinib, a novel, selective BCR-ABL inhibitor, fits into the ATP-binding site of the BCR-ABL protein with higher affinity than imatinib. Nilotinib is not only more potent than imatinib against wild-type BCR-ABL (IC50 < 30nM), but also significantly active against 32/33 imatinib-resistant BCR-ABL mutants. Melting Point: 242.5-245ºC Solubility: Soluble in DMSO at 50mg/ml; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20uM; buffers, serum, or other additives may increase or decrease the aqueous solubility. Elemental Analysis: Calculated C - 63.51% H - 4.19% F - 10.76% N - 18.52% Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.