N0019-66

Natriuretic Peptide Receptor Bi, isoform a (Not for Export EU)

Size

£390.00

SKU:: N0019-66
Purity:: Serum
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic human NPR-Bi isoform a, bTG. conjugated
Format:: Supplied as a lyophilized powder in PBS, pH 7.2. Reconstitute in ddH2O.
Extra Details:: ANPB (natriuretic peptide receptor B) is one of two integral membrane receptors for natriuretic peptides. Both ANPA and ANPB contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain), an helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. ANPB is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Applications: Suitable for use in Immunohistochemistry and Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:100 Immunohistochemistry: 1:10,000, cryo sections Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.