NALP3, CT (NACHT, LRR and PYD Domains Containing Protein 3, NLR Family Pyrin Domain Containing 3, NLRP3, AGTAVPRL, AII, AII/AVP, AVP, Angiotensin/vasopressin Receptor AII/AVP-like, C1orf7, Caterpiller Protein 1.1, CLR1.1, Cold Autoinflammatory Syndrome 1 Protein, CIAS1, Cryopyrin, FCAS, FCU, FLJ95925, MWS, PYRIN-containing APAF1-like Protein 1, PYPAF1)

Size

£696.00

SKU:: N0018-64H
Purity:: Purified by Protein A and peptide affinity chromatography
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 65-91 in the N-terminal region of human NALP3, UniProt Accession #NP_004886.3; Q96P20.
Format:: Supplied as a liquid in PBS, 0.09% sodium azide.
Extra Details:: NLRP3 is a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Western Blot: 1:1000 Immunohistochemistry (FFPE): 1:10-1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.