N0018-63G
NALP2 (NACHT-, LRR- and PYD-Containing Protein 2, Nucleotide-binding Site Protein 1, PYRIN Domain and NACHT Domain-containing Protein 1, PYRIN-containing APAF1-like Protein 2, NLRP2, NBS1, PAN1, PYPAF2)
Size
£825.00
- SKU:
- N0018-63G
- Application:
- WB
- Purity:
- Purified by Protein G affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Recombinant protein corresponding to aa1-208 of human NALP2 expressed in E. coli (Q9NX02).
- Clone:
- 11C41
- Format:
- Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute in 100uL of PBS, 0.02% sodium azide.
- Extra Details:
- NALP2 (NAcht Leucine-rich repeat Protein 2, also known as PAN1) is a cytosolic, 121kD member of the NLRP family of proteins. It is expressed in macrophages and exhibits divergent effects on inflammation. Via NFkB, it suppresses TNF-alpha production in response to LPS; via procaspase-1, it promotes proIL-1-beta cleavage and release. Human NALP2 is 1062aa in length. It contains an N-terminal Pyrin domain (aa9-90), followed by a Nacht region and nine LRRs (aa467-1033). Four alternate isoforms exist. Three show deletions of aa109-132, 133-154 and 847-1062, respectively; a fourth shows a 38aa substitution for aa1-903. No close rodent counterparts have been reported. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilutions: Western Blot: 1ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Shipping Conditions:
- Blue Ice