MYC, phosphorylated (Thr58) (Myc Proto-oncogene Protein, c-Myc, Proto-oncogene c-Myc, Transcription Factor p64, Class E Basic Helix-loop-helix Protein 39, bHLHe39)

Size

£696.00

SKU:: M9600-96F
Purity:: Purified by immunoaffinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic phosphopeptide corresponding to amino acid residues surrounding Thr58 of human MYC (KLH).
Format:: Supplied as a liquid in PBS, 0.09% sodium azide.
Extra Details:: MYC participates in the regulation of gene transcription. It binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. This protein appears to activate the transcription of growth-related genes. Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors. A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Applications: Suitable for use in ELISA, Western Blot, and Dot Blot. Other applications not tested. Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:50-1:200 Dot Blot: 1:100-1:500 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.