M4688-27D

MRP5 (Multidrug Resistance-associated Protein 5, ABC33, ATP-binding Cassette Sub-family C Member 5, ABCC5, Multi-specific Organic Anion Transporter C, MOATC, MOAT-C, pABC11, SMRP)

Size

£709.00

SKU:: M4688-27D
Purity:: Supernatant
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rat
Immunogen:: Bacterial fusion protein of mouse Mrp5 containing aa1-38.
Clone:: M5I-10
Format:: Supplied as a liquid in 0.7% BSA, 0.09% sodium azide.
Extra Details:: Multidrug Resistance-associated Protein 5 (MRP5) is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear. Applications: Suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:20-1:50 Immunohistochemistry (acetone fixed frozen): 1:20 Immunocytochemistry (acetone fixed): 1:20-1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice