MRP1 (Multidrug Resistance-associated Protein 1, ATP-binding Cassette Sub-family C Member 1, Leukotriene C(4) Transporter, LTC4 Transporter, MRP, ABCC1)

Size

£642.00

SKU:: M4688-18G
Purity:: Purified by immunoaffinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Goat
Immunogen:: Synthetic peptide corresponding to C-HQSDLKVDENQKAYY, from human ABCC1, at the internal region of the protein (NP_004987.2, NP_063915.2, NP_063953.2, NP_063954.2, NP_063955.2).
Format:: Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Extra Details:: Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:128,000 Western Blot: 0.05-0.2ug/ml, observed in lysates of cell line A549 on ~150kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.