M4675-71-ML650
Mortality Factor 4 (MORF4, CSR, SEN, CSRB, SEN1) (MaxLight 650)
Size
£902.00
- SKU:
- M4675-71-ML650
- Purity:
- Purified by immunoaffinity chromatography.
- Storage Conditions:
- 4°C Do Not Freeze
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- A peptide corresponding to an 18aa peptide from near the amino terminus of human MORF4.
- Format:
- Supplied as a liquid in PBS, pH 7.2. Labeled with MaxLight™650.
- Extra Details:
- MaxLight™650 is a new Far-IR stable dye conjugate comparable to Alexa Fluor™647, DyLight™649, Cy5™ and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (655nm); Emission (676nm); Extinction Coefficient 250,000. Mortality Factor 4 (MORF4), known also as SEN1 and cellular senescence-related protein 1. MORF4 is a nuclear localized protein possessing transcription factor-like motifs such as helix-loop-helix and a leucine zipper motif that are believed to allow it to form transcriptionally active homo- or heterodimers. MORF4 has been shown to bind to the transcription co-repressors mSin3A and TLE, suggesting that together, these complexes may play a role in transcriptional repression of genes that lead to cellular senescence. Applications: Suitable for use in Immunohistochemistry (paraffin) and Western Blot. Other applications not tested. Recommended Dilution: Immunohistochemistry (paraffin): 5ug/ml Western Blot: 1ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human brain tissue Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight™650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.
- Shipping Conditions:
- Blue Ice