M3895-08
Migration Inhibitory Factor Related Proteins 8 and 14 (MIF, MRP 8 and 14)
Size
£732.00
- SKU:
- M3895-08
- Purity:
- Purified from ascites
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Neutrophils
- Clone:
- 2Q1841 (AHN-17)
- Format:
- Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
- Extra Details:
- MIgration inhibitory factor-related proteins -8 and -14 belong to the S-100 family of calcium binding proteins associated with myeloid cell differentiation. They are highly expressed in resting neutrophils, keratinocytes (particularly in psoriasis), in infiltrating tissue macrophages and on epithelial cells in active inflammatory disease. The heterogeneity of macrophage subpopulations in chronic or acute inflammation is reflected by different expression of MRP8 and MRP14. Phagocytes expressing MRP8 and MRP14 belong to the early inflitrating cells while MRP8 alone is found in chronic inflammatory tissues. The partially antagonistic functions of MRP8, MRP14 and of the Ca2+ dependent MRP8/14 heterocomplex make them versatile mediators. Applications: Suitable for use in Immunocytochemistry and Western Blot. Other applications have not been tested. Recommended Dilutions: Immunocytochemistry: Ethanol fixed cells Western Blot: Non-reduced gels Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice