M2825-14F1
CD243 (Low Endotoxin, Azide Free)
Size
£544.00
- SKU:
- M2825-14F1
- Purity:
- Purified by Protein A affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- NIH 3T3 cells transfected with human CD243 (MDR-1) cDNA
- Clone:
- UIC2
- Format:
- Supplied as a liquid in PBS, pH 7.4. No preservative added.
- Extra Details:
- CD243, also known as multidrug resistant protein 1 (MDR-1) or P-glycoprotein (Pgp) is an ATP binding cassette (ABC)-containing efflux transporter for xenobiotic lipophilic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. It is expressed in many tissues, including the brain, liver, pancreas, testes, kidney, and blood (B, T, NK cells, but not monocytes). Applications: Suitable for use in Flow Cytometry, Functional Assays (Inhibition), Immunohistochemistry and Immunoprecipitation. Other applications not tested. Recommended Dilutions: Flow Cytometry: 1-4ug/ml Immunohistochemistry: frozen and paraffin sections. Heat mediated antigen retrieval in citrate buffer pH 6. required for paraffin sections. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice