M2158-10E
MAML1 (Mastermind-like Protein 1, Mam-1, KIAA0200)
Size
£642.00
- SKU:
- M2158-10E
- Purity:
- Purified by immunoaffinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Goat
- Immunogen:
- Synthetic peptide corresponding to VLPTCPMAEFALPR from human MAML1 at N-terminal. Species Sequence Homology: mouse
- Format:
- Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
- Extra Details:
- Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. Applications: Suitable for use in Peptide ELISA, Immunohistochemistry and Western Blot. Other applications not tested. Recommended Dilution: Peptide ELISA: 1:128,000 Immunohistochemistry (Paraffin): 2.5-3.8ug/ml Western Blot: 0.1-0.3ug/ml, observed in human skeletal muscle lysates on ~110kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice