M2148-05
MALT1 (MLT1, Mucosa Associated Lymphoid Tissue Lymphoma Translocation Gene 1, Paracaspase 1)
Size
£869.00
- SKU:
- M2148-05
- Application:
- WB
- Purity:
- Purified by Protein G affinity chromatography from hybridoma culture supernatant.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Recombinant protein corresponding to Asp701-Thr808 from human MALT1. Species Sequence Homology: mouse and rat, 87%
- Clone:
- 9H157
- Format:
- Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 200ul sterile PBS.
- Extra Details:
- Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is an ~91kD intracellular adaptor protein that forms a complex with Bcl10 and CARMA-1. The caspase-like domain of MALT1 cleaves Bcl10 and the NFkB inhibitor A20. This results in NFkB activation following signal transduction from cell surface ITAM-containing receptors including the T cell and B cell antigen receptors. Applications: Suitable for Western Blot. Other applications not tested. Recommended Dilutions: Western Blot: 1ug/ml using Jurkat human acute T cell leukemia cell line and Daudi human Burkitt's lymphoma cell line Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Shipping Conditions:
- Blue Ice