M1750-01D

MAGE A

Size

£735.00

SKU:: M1750-01D
Purity:: Purified by Protein A affinity chromatography from ascites.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Full-length recombinant human MAGE-A.
Clone:: 6A111
Format:: Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
Extra Details:: The MAGE-A protein is expressed in many types of tumors including melanoma, breast and lung. However, in normal tissues, it is only present in adult testis and placenta. The family of MAGE-A proteins includes MAGE-1, -2, -3, -4, -6, -10, and -12. MAGE-1, -3, -6 and -10 are able to recognize specific cytolytic T lymphocytes derived from tumors or peripheral blood. Additionally, MAGE-3 shows HLA class II restricted epitopes. Therefore, MAGE-A is regarded as a possible immunotherapy candidate, with clinical studies currently underway involving immunization with MAGE-1 and -3 peptides. Applications: Suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot. Other applications have not been tested. Recommended Dilutions: Immunohistochemistry: Frozen sections Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.