L9190-10N
LAMP1 (Lysosome-associated Membrane Glycoprotein 1, LAMP-1, Lysosome-associated Membrane Protein 1, CD107 Antigen-like Family Member A, CD107a)
Size
£338.00
- SKU:
- L9190-10N
- Purity:
- Purified by affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Human adult adherent peripheral blood cells.
- Clone:
- H4A3
- Format:
- Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
- Extra Details:
- CD107a, also known as Lysosome-Associated Membrane Protein 1 (LAMP-1) or LGP-120, is a 110-140kD type I membrane glycoprotein. The mature CD107a is heavily glycosylated from a 40kD core protein. It is expressed by activated platelets, activated lymphocytes, macrophages, epithelial cells, endothelial cells, and some tumor cells. This molecule is located on the luminal side of lysosomes and has been suggested to play a role in the protection of lysosome membrane from lysosomal hydrolases. Upon activation, CD107a is transferred to the cell membrane surface. It plays a role in cell adhesion and regulation of tumor metastasis, and mediates autoimmune disease progression. CD107a is a ligand for galaptin and E-selectin. Applications: Suitable for use in Flow Cytometry, Western Blot, Immunocytochemistry and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Flow Cytometry: ≤2ug/10e5 cells in 100ul Western Blot: 1-5ug/ml Immunohistochemistry (FFPE): 5-10ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice