L3450
Lovastatin (Mevinolin)
Size
£171.00
- SKU:
- L3450
- Molecular Weight:
- 404.5
- Storage Conditions:
- 4°C
- Supplier:
- United States Biological
- CAS Number:
- 75330-75-5
- Extra Details:
- Cancer cell line apoptotic inducer via HMG-CoA reductase mechanism. Statin compound. Potent competitive HMG-CoA reductase inhibitor. Anti-hypercholesterolemic agent. Cholesterol/isoprenoid biosynthesis inhibitor. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids. Inhibits the isoprenylation of Ras and Rho family GTPases. Causes cell cycle arrest in G1 and G2/M phases through modulation of proteasome in cancer cell lines. Smooth muscle cell proliferation inhibitor. Apoptosis inducer. Anticancer compound. Anti-adhesive, immunomodulatory and anti-inflammatory compound. Stimulates bone formation. Increases cellular resistance to anticancer agents such as doxorubicin and etoposide. Suppresses ICAM-1-LFA-1 interactions, which blocks virus replication and infection. Anti-hypertensive agent. Suppresses TNF-induced NF-kappaB activation. Modulates key cell signaling pathways, like Ras, MAPK and EGFR (modest). Synonyms: Mevinolin; 6a-Methylcompactin; Monakolin K; MK-803, 6-alpha-Methylcompactin; BRN 3631989 Source: Aspergillus sp. CAS Number: 75330-75-5 Molecular Formula: C24H36O5 Molecular Weight: 404.5 Purity: ≥98.5% Appearance: White crystalline powder Solubility: Soluble in DMSO and ethanol Loss on Drying: ≤0.1% Heavy Metals: ≤0.002% Specific Rotation: +324°-338° Residue on Ignition: ≤0.2% Indentification (Infrared, UV): Conforms to reference Exceeds USP Specifications
- Shipping Conditions:
- Ambient