L2601-02F
Lipoprotein Receptor, Low Density (Low-density Lipoprotein Receptor, LDL Receptor, LDLR, Familial Hypercholesterolemia, FH, FHC, LDLCQ2)
Size
£696.00
- SKU:
- L2601-02F
- Purity:
- Purified by Protein A and peptide affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 391-419 in the central region of human LDLR. Species Sequence Homology: Xenopus, bovine, hamster, porcine, rabbit and rat
- Format:
- Supplied as a liquid in PBS, 0.09% sodium azide.
- Extra Details:
- The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Applications: Suitable for use in ELISA, Indirect Flow Cytometry and Western Blot. Other applications not tested. Recommended Dilutions: Western Blot: 1:1000 Indirect Flow Cytometry: 1:10-1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice