L2050
Leupeptin Hemisulfate
Size
£146.00
- SKU:
- L2050
- Molecular Weight:
- 426.55
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- CAS Number:
- 103476-89-7
- Format:
- White powder
- Extra Details:
- Leupeptin is a reversible competitive inhibitor of serine and thiol proteases that competes with substrate for the active site of the enzyme. It has been reported to inhibit calpain, cathepsin B and trypsin, for example. Leupeptin is often used for the inhibition of plasmin, trypsin, papain, kallikrein and cathepsin B. No inhibition found with pepsin, cathepsins A and D, elastase, renin or chymotrypsin. A typical working concentration is in the range of 10-100uM Leupeptin has 3 tautomeric isomers which are separated by chromatography. Synonyms: Microbial Leupeptin; Acetyl-Leu-Leu-Arg-al; Leupeptin hemisulfate salt; N-Acetyl-L-leucyl-L-leucyl-L-argininal hemisulfate salt CAS No: 103476-89-7 Molecular Formula: C20H38N6O4•1/2H2SO4 Molecular Weight (Sulfate Form) (Ac-Leu-Leu-Argininal): 426.55 Appearance: White powder Optical Rotation: -80.0° ± 2° Water: ≤5% Specific Activity (Trypsin/TAME): ~1.2ug/ml Solubility: Soluble in water, ethanol, acetic acid and DMF. Clear to v.slightly hazy solution at 50mg/mL in water. Storage and Stability: Lyophilized powder may be stored at -20°C. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Product is stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Shipping Conditions:
- Ambient