L2028-09

Leukocyte Immunoglobulin-like Receptor 2 (Leukocyte Immunoglobulin-like Receptor Subfamily B Member 2, LILRB2, LIR2, LIR-2, CD85 Antigen-like Family Member D, CD85d, Immunoglobulin-like Transcript 4, ILT4, ILT-4, LILRA6, Monocyte/macrophage Immunoglobulin-like Receptor 10, MIR10, MIR-10, Leukocyte Immunoglobulin-like Receptor, Subfamily B (with TM and ITIM Domains), Member 2) (Azide Free)

Size

£685.00

SKU:: L2028-09
Application:: WB
Purity:: Purified
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Recombinant protein corresponding to a portion of amino acids within aa22-599 of human LILRB2 with a GST Tag. MW of tag alone is 26kD. (Q8N423, AAH36827).
Clone:: 11C374
Format:: Supplied as a liquid in PBS, pH 7.2. No preservative added (Azide free).
Extra Details:: The gene encoding this protein is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilutions: Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice