Leucine Rich Repeat And Ig Domain Containing 1 (LINGO1, LERN1, LRRN6A)

Size

£709.00

SKU:: L2020-73D
Application:: IHC-Fr
Purity:: Purified by immunoaffinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide corresponding to human LINGO1 at C-terminal (KLH).
Format:: Supplied as a liquid in PBS, 0.09% sodium azide.
Extra Details:: LINGO-1 (Leucine-rich repeat- and Ig domain-containing nogo receptor-interacting protein 1) is a transmembrane protein of the leucine-rich repeat (LRR) family, ribonuclease inhibitor subfamily. The four known LINGO proteins contain LRR and IgCAM domains in the extracellular portion and share 44-61aa identity. LINGO-1 is restricted to the nervous system and is concentrated in the brain as a component of the NgR1/p75 and NgR1/Taj (Troy) signaling complexes. LINGO-1 negatively regulates neurite outgrowth and myelination, and is highly conserved, showing 99aa identity between human, mouse and rat. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 20ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.