L1671-38A

Leptomycin B (Elactocin, Antibiotic ATS 1287B, Antibiotic CI 940, Antibiotic CL 1957A, Antibiotic PD 114720, Mantuamycin)

Size

£473.00

SKU:: L1671-38A
Molecular Weight:: 540.7
Purity:: ~99% by HPLC
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 87081-35-4
Format:: Colorless film
Extra Details:: Leptomycin B is the dominant and most studied member of the leptomycin class isolated from selected Streptomyces strains. Leptomycin B is a nanomolar active and specific nuclear export inhibitor. Its target is CRM1/exportin1 a protein in the nuclear export sequence (NES). Examples of proteins affected are c-Abl, cyclin B1, HIV-1 Rev, IκB, MPF, MAP/ERK, MDM2/p53, NF-κB/IκB7 and PKA. Export of many RNAs are also inhibited e.g. COX-2 and c-FOS mRNA. In addition Leptomycin B shows antifungal and antibacterial and potent antitumour activities. Solubility: Soluble in ethanol or methanol. Poor water solubility. Ethanol is recommended. Unstable in DMSO. Storage and Stability: Stable for 6 months after receipt at -20°C. Related to: Anguinomycin A, Leptomycin A, Kazusamycin A, Kazusamycin B