K6750
KSHV GPCR (Kaposi's Carcinoma-associated Herpes Virus, KSHV, Human Herpes Virus 8, HHV8)
Size
£397.00
- SKU:
- K6750
- Application:
- Flow Cytometry
- Purity:
- Purified by Protein A affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to a fragment of residues within amino acids 1-41 in the N-terminal region of human KSHV GPCR., expressed in E. coli.
- Format:
- Supplied as a liquid, 0.05% sodium azide.
- Extra Details:
- Kaposi's sarcoma-associated herpesvirus (KSHV, or human herpesvirus 8, HHV8), is a gamma herpesvirus that contain an open reading frame encoding a G protein-coupled receptor (GPCR) with putative 7 transmembrane domains. This GPCR has been shown to bind a number of chemokines including IL-8, NAP-2, PF-4, MGSA/Groa, I-309, RANTES, MCP-1, and MIP-1b. The receptor is constitutively activated without chemokine binding, and it stimulates cell proliferation. KSHV GPCR is also a viral oncogene that stimulates angio-genesis through induction of VEGF expression. IP-10, a chemokine, can inhibit constitutively activated KSHV GPCR. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice