K1765-30

Kijanimicin (Antibiotic Sch 25663)

Size

£473.00

SKU:: K1765-30
Molecular Weight:: 1317.5
Purity:: ~99% by HPLC
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 78798-08-0
Format:: Supplied as a white solid.
Extra Details:: Kijanimicin is a tetronic acid related to saccharocarcin, chlorothricin, versipelostatin and tetrocarcin. Like the tetrocarcins, kijanimicin contains an unusual nitro-aminoglycoside. Kijanimicin is a potent antibacterial, antimalarial and antitumor activity. However, several members of this class have received considerable literature focus. Versipelostatin was shown to inhibit transcription from the promoter of GRP78, a gene that is activated as part of a stress signaling pathway under glucose deprivation resulting in unfolded protein response (UPR). The UPR-inhibitory action was seen only in conditions of glucose deprivation and caused selective and massive killing of the glucose-deprived cells. While tetrocarcin A appears to target the phosphatidylinositide-3'-kinase/Akt signaling pathway. Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute by adding ethanol, methanol, DMF or DMSO. Aliquot and store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.