I8611-02
Irinotecan, Hydrochloride Salt, Trihydrate
Size
£249.00
- SKU:
- I8611-02
- Molecular Weight:
- 677.18
- Purity:
- ≥99% (HPLC/TLC)
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- CAS Number:
- 136572-09-3
- Format:
- White to off-white solid
- Extra Details:
- Irinotecan (CPT-11) is a topoisomerase I inhibitor. It is a semisynthetic analog of the natural alkaloid camptothecin and has an active metabolite SN-38 (7-Ethyl-10-hydroxycamptothecin). During the S phase of the cell cycle, camptothecins selectively bind to and stabilize topoisomerase I-DNA complexes, inhibiting religation, causing the accumulation of topoisomerase I-mediated single-strand DNA breaks in the DNA, and producing irreversible double-strand DNA breaks that lead to cell death. Synonyms: [1,4'-Bipiperidine]-1'-carboxylic Acid (4S)-4,11-Diethyl-3,4,12,14- tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl Ester Hydrochloride Trihydrate; Campto; CPT11; Irinotecan hydrochloride trihydrate CAS No: 136572-09-3 Anhydrous: 100286-90-6; Anhydrous Free Base: 97682 Molecular Formula: C₃₃H₄₅ClN₄O₉ Molecular Weight: 677.18 Appearance: White to off-white solid Purity (HPLC): ≥99% Purity (TLC): ≥99% Melting Point: >245°C (dec.) Solubility: Methanol (Sparingly); Soluble in DMSO at 100mg/ml; very poorly soluble in ethanol; soluble in water at 25mg/ml; buffers, serum, or other additives may increase or decrease the aqueous solubility. Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
- Shipping Conditions:
- Blue Ice