I8465

IPP-POZ Domain, aa1-157, Recombinant, Human (Intracisternal A Particle-promoted Polypeptide)

Size

£819.00

SKU:: I8465
Molecular Weight:: 17.3
Purity:: ≥ 95% by SDS PAGE; Purified by conventional column chromatography techniques.
Storage Conditions:: -20°C
Supplier:: United States Biological
Format:: Supplied as a liquid in 10mM HEPES, pH 7.4, 25mM sodium chloride.
Extra Details:: Intracisternal A particle-promoted polypeptide (IPP) is a 66kD protein (584 amino acids), which contains an N-terminal POZ protein-protein interaction domain and a C-terminal kelch repeat domain consisting of six tandem arranged repeats. The POZ domain (also called BTB domain) is present near the N-terminus of a fraction of zinc finger proteins and in protein that contain the pfam01344 motif such as kelch and pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-coR and SMRT. Recombinant protein corresponding to aa1-157 from human IPP-POZ Domain, expressed in E. coli. Molecular Weight: ~17.3kD (157 amino acids) Amino Acid Sequence: MANEDCPKAA DSPFSSDKHA QLILAQINKM RNGQHFCDVQ LQVGQESFKA HRLVLAASSP YFAALFTGGM KESSKDVVPI LGIEAGIFQI LLDFIYTGIV NIGVNNVQEL IIAADMLQLT EVVHLCCEFL KGQIDPLNCI GIFQFSEQIA CHDLLEF Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing.. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Shipping Conditions:: Blue Ice