I8439-21C
Interleukin 17 Receptor D (IL-17RD)
Size
£832.00
- SKU:
- I8439-21C
- Purity:
- Purified by Protein A affinity chromatography from cell culture supernatant.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Recombinant protein corresponding to Ala27-Arg299 from the extracellular domain of human IL-17RD expressed in NS0 cells.
- Clone:
- 8H141
- Format:
- Supplied as a lyophilized powder from PBS, pH 7.4, 5% trehalose. Reconstitute with 200ul sterile PBS.
- Extra Details:
- Interleukin 17 Receptor D (IL-17RD), also known as Sef (similar expression to FGFs), is a type I transmembrane IL-17R-related protein that can bind to FGF receptors 1 and 2 and antagonize ERK signaling by preventing translocation to the nucleus. The full-length 739aa hSef-a isoform is a 120kD cell surface glycoprotein expressed in most tissues (except thyroid). Three other isoforms have alternate N-termini shortened by 24, 32 or 144aa. Isoform hSef-b is an 80kD non-glycosylated intracellular Golgi membrane protein within thyroid, testes, pituitary and fetal brain. Human IL-17RD shows 90% aa identity with mouse IL-17RD in the extracellular/lumenal region. Applications: Suitable for use in Western Blot and Direct ELISA. Other applications have not been tested. Recommended Dilutions: Western Blot: 1ug/ml using recombinant human Interleukin 17 Receptor D Optimal dilutions to be determined by the researcher. Hybridoma: Produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Shipping Conditions:
- Blue Ice