Interleukin 12 beta Chain (Interleukin 12b, Interleukin-12b, IL12b, IL-12b, Interleukin 12 p40, IL-12 p40, IL12 Subunit p40, IL-12 Subunit p40, Interleukin 12 Subunit beta, 40kD Subunit, Cytotoxic Lymphocyte Maturation Factor 2 p40, CLMF 2, CLMF2, Cytotoxic Lymphocyte Maturation Factor 40kD Subunit, CLMF p40, HGNC:5970, Natural Killer Cell Stimulatory Factor 2, Natural Killer Cell Stimulatory Factor 40kD Subunit, NK Cell Stimulatory Factor Chain 2, NKSF 2, NKSF2, NKSF, Subunit P40)

Size

£642.00

SKU:: I8434-27D
Application:: WB
Purity:: Purified by immunoaffinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Goat
Immunogen:: Synthetic peptide corresponding to C-EARQQNKYENYS from the internal region of mouse Il12b/Il12p40 (NP_032378.1).
Format:: Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Extra Details:: IL-12 is a heterodimer composed of subunits IL-12A p35 and IL-12B p40. Autocrine IL-12 is responsible for the differentiation of naive CD4+T cells into type 1 helper T cells (Th1) that produce interferon-_ (IFN-_). Expression of STAT 4, a signal transduction molecule important in cytokine-induced gene expression, appears central to IL-12 induced Th1 production of IFN-_. It also activates production of tumor necrosis factor (TNF) from T and natural killer cells. IL-12 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:4000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.