I7663-25L3
Interleukin 1 Receptor Antagonist, Recombinant, Human (IL-1RA, IL1RA, IL-1ra3, IL-1RN, IL1RN, Anakinra, DIRA, ICIL-1RA, IL1 Inhibitor, IL1F3, IRAP, MVCD4)
Size
£492.00
- SKU:
- I7663-25L3
- Molecular Weight:
- 17.2
- Purity:
- ≥98% (SDS PAGE). Endotoxin: ≤0.1ng/ug
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Format:
- Supplied as a lyophilized powder from TBS. No preservative added. Reconstitute with sterile dH2O, 0.1% HSA or BSA to 0.1-1mg/ml.
- Extra Details:
- Interleukin-1 receptor antagonist (IL-1RA) is a naturally-occurring, inflammatory-inhibitor protein. It inhibits the activity of IL-1a and IL-1b by competitively blocking their binding to type I and type II receptors. IL-1RA is produced by corneal epithelial cells, monocytes, neutrophils, macrophages, and fibroblasts. Therapeutically, IL-1RA may help in the treatment of sepsis, cachexia, rheumatoid arthritis, chronic myelogenous leukemia, asthma, psoriasis, and inflammatory bowel disease. Recombinant Human IL-1RA is a 17.2kD protein consisting of 153 amino acid residues. Recombinant protein corresponding to human IL-1RA, expressed in E. coli. Amino Acid Sequence: MRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDE Biological Activity: The ED50 as determined by an assay of dose dependent inhibition of IL-1a stimulation of mouse D10S cells was expected to be 20-40ng/ml in the presence of 50pg/ml of IL-1a. Storage and Stability: Lyophilized and reconstituted products may be stored at -20°C. Stable for 6 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Shipping Conditions:
- Blue Ice