I7661-46B
Integrin, beta8
Size
£863.00
- SKU:
- I7661-46B
- Purity:
- Purified by Protein A affinity chromatography from hybridoma culture supernatant.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Recombinant protein corresponding to Glu43-Arg684 from human Integrin b8, expressed in NS0 cells.
- Clone:
- 8H177
- Format:
- Supplied as a lyophilized powder from PBS, pH 7.4, 5% trehalose. Reconstitute with 200ul sterile PBS.
- Extra Details:
- Integrin beta 8 (Integrin b8) is a 90kD type I transmembrane glycoprotein of the Integrin family of adhesion molecules. It associates with Integrin aV to form a receptor for vitronectin, fibrin, and the latency associated peptide (LAP). Binding to LAP promotes the proteolytic release of active TGF-b from LAP. Integrin aVb8 is required for vascular morphogenesis in the embryonic brain and yolk sac. Within the extracellular domain, human Integrin b8 shares 87% aa sequence identity with mouse and rat Integrin b8. Applications: Suitable for use in Flow Cytometry and Direct ELISA. Other applications not tested. Recommended Dilutions: Flow Cytometry: 0.25ug/10e6 cells using WM-115 human melanoma cell line. Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Shipping Conditions:
- Blue Ice