I7661-44-APC

Integrin beta6 (APC)

Size

£1,023.00

SKU:: I7661-44-APC
Purity:: Purified
Storage Conditions:: 4°C Do Not Freeze
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Immunization of beta6 knockout mice with recombinant secreted human alphaVbeta6. Epitope: Unknown whether the epitope recognized by the antibody localizes to the alphaVbeta6 heterodimer or to the beta6 subunit only.
Clone:: 2Q790 (CSb6)
Format:: Supplied as a liquid in PBS, pH 7.2. Labeled with Allophycocyanin (APC).
Extra Details:: Integrins are a large family of transmembrane proteins composed of an alpha and beta component. Integrins are involved in a diversity of biological functions such as cell adhesion, structure, differentiation, apoptosis and cell proliferation. They are the principal cell surface receptors that recognize cell to matrix interactions, but little is known about the expression of beta 1 integrin family on airway smooth muscle (ASM) and their involvement in proliferation. This is a contributing factor in structural changes seen in asthma. Applications: Suitable for use in Flow Cytometry, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry. Not suitable for use in Western Blot. Other applications have not been tested. Recommended Dilutions: Flow Cytometry: Effective for all species tested. Immunohistochemistry: Acetone fixation. Effective for rabbit, rat, monkey and human. Not suitable for use on mouse tissue. Immunocytochemistry: Effective for F6, HT-29, H441 cell lines. Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Shipping Conditions:: Blue Ice