I7502-76D
Immunoglobulin-Like Transcript 7 (ILT7, CD85k)
Size
£825.00
- SKU:
- I7502-76D
- Application:
- Flow Cytometry
- Purity:
- Purified by Protein G affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Recombinant corresponding to ILT7/CD85g from human ILT7 expressed in NSO cells.
- Clone:
- 11D30
- Format:
- Supplied as a lyophilized powder from PBS, pH 7.4, 5% trehalose. Reconstitute with 200ul sterile PBS.
- Extra Details:
- LILRA4, also known as ILT7 and CD85g, is a 499 amino acid (aa) type I transmembrane glycoprotein that contains four Iglike domains in its extracellular region. LILRA4 is selectively expressed on plasmacytoid dendritic cells (pDC). It binds to BST2/CD317 on bone marrow stromal cells and associates with the gamma subunit of Fc epsilon RI. This receptor complex transmits signals that inhibit the TLRinduced production of type I interferon. The LILRA4mediated interactions between pDC and tumor cells similarly inhibit the production of proinflammatory cytokines and contribute to reduced antitumor immune responses. Alternate splicing of human LILRA4 generates an isoform that lacks the Nterminal 43 aa of the extracellular domain. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Flow Cytometry: 2.5ug/10e6 cells. Detection of ILT7/CD85g in Human PBMCs. Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Shipping Conditions:
- Blue Ice