I2500-40
IkB zeta (IkappaB zeta, IKBZ, FLJ30225, FLJ34463, INAP, Molecule Possessing Ankyrin Repeats Induced by Lipopolysaccharide, MAIL Protein, Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B cells Inhibitor zeta, NFKBIZ)
Size
£537.00
- SKU:
- I2500-40
- Application:
- WB
- Purity:
- Purified by Protein G affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Synthetic peptides corresponding to aa684-699 RKGADPSTRNLENEQP and aa285-298, YQYSPQTQNMQQPP of mouse IkBz protein (NP_085115.1). Species Sequence Homology: human, rat, bovine and primate; 100%, chicken; 93%
- Format:
- Supplied as a liquid in PBS, pH 7.4, 0.2% gelatin, 0.05% sodium azide.
- Extra Details:
- IkappaB zeta (also known as MAIL and INAP) is an ankyrin-repeat-containing nuclear protein that is highly homologous to the IkappaB family member Bcl-3. Transcription of IkappaBzeta is upregulated by stimulation with TLR ligands, IL-1 and IL-6 in cultured B-lymphocytes and monocytes/macrophages, but only faintly so in T-lymphocytes, fibroblasts, and endothelial cells. IkappaB-zeta preferentially associates with the NF-kappaB subunit p50 rather than p65 and recombinant IkappaB-zeta proteins inhibit the DNA binding of the p65/p50 heterodimer and the p50/p50 homodimer. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilutions: Western Blot: 1-3ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice