Pravastatin Sodium Salt

Size

£301.00

SKU:: H9111-27B
Molecular Weight:: 446.5
Purity:: ~98% (HPLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 81131-70-6
Format:: Supplied as a white powder.
Extra Details:: Pravastatin sodium is the sodium salt of pravastatin, a ring- opened member of the statin family. Pravastatin is produced biosynthetically from compactin (mevastatin) by a number of micro-organisms, notably Absidia, Cunninghamella, Syncephalastrum, Nocardia or Streptomyces. Typically, statins like compactin, lovastatin and simvastatin possess a b-hydroxy lactone ring which is a pro-drug for the readily ring-opened dihydroxyacid generally regarded as the active HMG-CoA inhibitor. Importantly, the free carboxylic acid enables pravastatin to be freely water soluble within biological pH ranges. Pravastatin is used therapeutically to reduce LDL cholesterol. Source: Pravastatin from Absidia sp. Molecular Weight: ~446.5 Solubility: Soluble in water, methanol and DMSO. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.