4-Hydroperoxycyclophosphamide (4-HC)

Size

£400.00

SKU:: H9015
Molecular Weight:: 293.08
Storage Conditions:: -86°C
Supplier:: United States Biological
CAS Number:: 39800-16-3
Extra Details:: A metabolite of Cyclophosphamide. Antineoplastic; bone marrow purging agent. 4-Hydroperoxy cyclophosphamide is the active metabolite form of the prodrug Cyclophosphamide. 4-Hydroperoxy cyclophosphamide crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide has the potential for lymphomas and autoimmune disorders. Synonyms: 2-[Bis(2-chloroethyl)amino]tetrahydro-2-oxido-2H-1,3,2-oxazaphosphorin-4-yl Hydroperoxide; 4-Hydroperoxycyclofosfamide; Asta 6496 CAS No: 39800-16-3 Molecular Formula: C7H15Cl2N2O4P Molecular Weight: 293.08 Purity: ≥98% Appearance: White to pale yellow solid Solubility: Chloroform (Slightly), Methanol (Slightly) Method for Determining Identity: 1H NMR, 31P NMR Spectroscopic and Mass Spectrometric Analysis Elemental Analysis: Calculated: %C: 28.69, %H: 5.16, %N:9.56 Specific Rotation: As reported Water Content (Karl Fischer): As reported Storage and Stability: Long-term storage is recommended at -70°C. Stable for 6 months after receipt. Hygroscopic and temperature sensitive. Store under inert atmophere.