H5203-97H

Histone Methyltransferase Set7/9 (Histone H3 Lysine 4 Specific Methyltransferase, H3 K4 HMTase, H4 Lysine-4 Specific, Histone H3 K4 Methyltransferase, Histone Lysine N-methyltransferase H3 Lysine 4 Specific SET7, FLJ21193, KIAA1717, SET 7/9, SETD7) (Not for Export EU)

Size

£576.00

SKU:: H5203-97H
Purity:: Serum
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Two synthethic peptides corresponding to amino acids 131-145 ([BLAST]GEVNEDGEMTGEKIA[/BLAST]) and 336-352 ([BLAST]GYDHSPPGKSGPEAPEW[/BLAST]) of human Set7/9 were used as immunogen; GenBank Accession No. NP_085151.1. These sequences are 100% conserved between human, mouse and rat.
Format:: Supplied as a liquid, 0.05% sodium azide.
Extra Details:: Diverse signal transduction pathways impinging on the N-terminal tails of histones lead to a number of post-translational modifications including acetylation, phosphorylation, poly(ADP-ribosylation), ubiquitination and methylation. These modifications play critical roles in regulating chromatin structure and gene expression. Histone methyltransferases (HMTases) selectively methylate evolutionarily conserved arginine or lysine residues, primarily in the N-terminal tails of histones H3 and H4. Set7/9 is a histone specific HMTase that methylates histone H3 lysine 4. Set7/9 transfers methyl groups to lysine 4 of histone H3 in complex with S-adenosyl-L-methionine. Human Set7/9 is a 336 amino acid protein. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice