H1892-51
Heparin Cofactor II (HCII)
Size
£351.00
- SKU:
- H1892-51
- Purity:
- Purified by caprylic acid and ammonium sulfate precipitations and solid-phase adsorption to remove unwanted crossreactivity.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Goat
- Immunogen:
- Human Heparin Cofactor-II (HCII) purified from plasma.
- Format:
- Supplied as a liquid in 10mM HEPES, pH7.4, 0.15M sodium chloride, 50% glycerol.
- Extra Details:
- Heparin Cofactor II (HCII) is also known as heparin cofactor A and dermatan sulfate cofactor. It is a single chain glycoprotein produced in the liver. It circuates in plasma at a concentration of 50-100ug/ml (0.8-1.5mM). HCII is a member of the Serpin family of proteinase inhibitors. HCII exhibits a relatively narrow specificity and is only know to inhibit the serine proteinases thrombin and chymotrypsin. The inhibitory activity toward thrombin is accelerated up to 1000- fold in the presence of optimal concentrations of heparin. Unlike Antithrombin, thrombin inhibition by HCII is also enhanced by dermatan sulfate. HCII has an apearent molucular weight of 65.6kD. Interaction with thrombin results in a covalent 1:1 enzyme-inhibitor complex of 102.6kD. Applications: Suitable for use in ELISA and Immunoelectrophoresis. Other applications not tested. Recommended Dilutions: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice