Heat Shock Protein 110 (HSP110)

Size

£550.00

SKU:: H1833-10B
Purity:: Purified by Protein A affinity chromatography
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide corresponding to the sequence of hamster Hsp 110. Sequence identical to human and mouse.
Format:: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide, 50% glycerol.
Extra Details:: HSP110, a member of the HSP110/SSE family of large stress proteins, plays a critical role in maintaining proteostasis under physiological and pathological conditions. Although distantly related to the HSP70 family, HSP110 shares 30–33% amino acid identity, particularly within the conserved ATP-binding domain, and functions cooperatively with HSP70 in the eukaryotic cytosol to facilitate protein folding and prevent aggregation. In mammals, HSP110 is constitutively expressed, with notably high levels in the brain. Its expression is further upregulated in response to cellular stress, including cerebral ischemia—a condition closely linked to neurodegenerative processes. Both HSP70 and HSP110 are elevated following ischemic events, suggesting a coordinated chaperone response. Interestingly, HSP110 deficiency has been associated with enhanced HSP70 activity, indicating a compensatory mechanism that may influence neuronal survival and recovery. Emerging evidence positions HSP110 as a key modulator of neuroprotection, particularly in the context of diseases characterized by protein misfolding and aggregation, such as Alzheimer’s, Parkinson’s, and Huntington’s disease. By stabilizing protein conformation and supporting cellular stress responses, HSP110 contributes to neuronal resilience and recovery. Beyond neuroscience, HSP110 is also being explored in cancer immunotherapy, highlighting its broader relevance in stress biology and therapeutic development. Its dual role in neuroprotection and immune modulation makes HSP110 a promising target in translational research focused on neurodegenerative disease intervention. Applications: Suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence/Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot:1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice